产品货号：
Z19244
中文名称：
KDM1/KDM1A抗体
英文名称：
Anti-KDM1/KDM1A Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KDM1/KDM1A Antibody |
| 指标别名 | AOF2;BHC110;KDM1;KDM1A;KIAA0601;LSD1;lysine (K) demethylase 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | KDM1A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-LSD1 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human LSD1.The immunogen is located within amino acids 40-90 of LSD1. |
| 计算分子量 | 93kDa |
| 成分 | LSD1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | LSD1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins.LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction.Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation,while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription.LSD1 associates with various proteins,including HDAC1/2,CoREST,and BHC80,that act to regulate LSD1 activity in vivo,and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation.Experiments have shown that CoREST,a SANT domain-containing corepressor acts to enhance LSD1 activity,while BHC80,a PHD domain-containing protein,inhibits CoREST/LSD1 activity in vitro.LSD1-mediated histone demethylation thus may have significant effects on gene expression. |
| Uniprot ID | O60341 |
| 基因名全称 | Lysine (K)-specific demethylase 1 |
| 蛋白名全称 | Lysine (K)-specific demethylase 1 |
| 推荐稀释比 | WB:0.2 ～ 2μg/mL;IHC:2μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human,mouse and rat samples;Immunohistochemistry and Immunofluorescence in human samples.All other applications and species not yet tested. |
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